The History Of Wellbutrin
Wellbutrin is the brand name for the drug bupropion. It was approved by the Food and Drug Administration to treat depression in 1985. From 1986 to 1989, it was removed from the market due to reports of epileptic seizures. The seizures were found to be dose-related, so when Wellbutrin returned to the market in 1989, the maximum dose was lowered.
Wellbutrin SR, the sustained-release version, was approved in 1996, and Wellbutrin XL, the extended-release version, in 2003. In 2006, it became the first medication approved to treat seasonal affective disorder .
The FDA has not approved Wellbutrin for the treatment of ADHD. However, it is prescribed by doctors as an off-label treatment option.
Research on Wellbutrin for ADHD is ongoing. For example, one study found it significantly lessened ADHD symptoms when compared to a placebo. Other studies on the effectiveness of Wellbutrin in aiding ADHD symptoms in adults have been promising.
What Is Lexapro What Is Wellbutrin How Do They Work
Lexapro is an oral drug that is used for treating depression and generalized anxiety disorder. Lexapro belongs to a class of antidepressant drugs called serotonin reuptke inhibitors . Lexapro prevents the reuptake of serotonin which results in more serotonin in the brain to attach to nerve receptors.
Drugs in the SSRI class also are used for treating obsessive compulsive disorders and panic disorders, although Lexapro is not approved for these purposes. Other SSRI antidepressants include fluoxetine , paroxetine and sertraline .
Wellbutrin is an antidepressant that also affects neurotransmitters. Wellbutrin works by inhibiting the reuptake of the neurotransmitters dopamine, serotonin, and norepinephrine, which results in more dopamine, serotonin, and norepinephrine to transmit messages to other nerves. Wellbutrin is unlike other antidepressants in that its major effect is on dopamine, an effect that is not shared by selective serotonin reuptake inhibitors or tricyclic antidepressants uses
Conditions Treated By Wellbutrin And Lexapro
Wellbutrin and Lexapro are both indicated in the treatment of major depression. MDD is characterized by prolonged feelings of low mood and decreased energy levels. It is possible that patients may not find joy in things they enjoyed previously.
Lexapro is also indicated in the treatment of generalized anxiety disorder . GAD is characterized by prolonged and obsessive worrying about a variety of topics.
Bupropion, the active ingredient in Wellbutrin, carries a unique indication for smoking cessation. Although the mechanism is not entirely understood, patients taking bupropion are more likely to be able to achieve smoking cessation. A systematic review of numerous studies with an overall large sample size supports this statement, though patients may experience more adverse events than with other smoking cessation interventions.
Wellbutrin and Lexapro are both used off-label in a variety of psychological disorders that are closely related to depression. The following is not intended to be a complete listing of potential uses for Wellbutrin and Lexapro. Only your healthcare professional can diagnose your disorder and decide which treatment option is best for you.
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Coverage And Cost Comparison Of Wellbutrin Vs Lexapro
Wellbutrin is a prescription medication that is typically covered by both commercial and Medicare drug plans. The out-of-pocket price for generic Wellbutrin XL 150 mg can be more than $175, but with a coupon from SingleCare, you could get it for around $15.
Lexapro is also a prescription medication that is typically covered by both commercial and Medicare drug plans. Similar to Wellbutrin, the out-of-pocket price for a 30 day supply of generic Lexapro 10 mg can be as much as $180. SingleCare offers a coupon for generic Lexapro, which lowers the price to $15.
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Structure Of This Drug
The main reason why this drug was a success was that when compared with the other drugs this drug has a different chemical structure and also that it can somehow influence the third type of the neurotransmitter chemical. The three chemicals of this neurotransmitter are serotonin, norepinephrine and dopamine. Actually all the drugs used to have their effect only on the two chemicals of the neurotransmitter where as this Wellbutrin and anxiety has its affect on the third chemical, thats its difference when compared with the others drugs.
When We Struggle With Our Mental Health Or A Depressive Disorder It Can Be Tough To Choose The Best Treatment Plan If Youre Considering Prescription Drugs Two Popular Antidepressants Are Wellbutrin And Lexapro
When we take a close look at Wellbutrin vs Lexapro, which comes out on top? The answer varies for each individual. But if youâre trying to decide which is best for you, it helps to look at each medication and see which may better suit your needs, health, and lifestyle. There are some significant differences between Lexapro and Wellbutrin, with each having its advantages and disadvantages.
In this Minded Guide, weâll take a closer look at both medications and what you need to know if youâre taking them for the first time or considering replacing Lexapro with Wellbutrin . This information can give you the confidence to make a sound decision.
Read on to learn more about the two medications, including:
- An introduction to Wellbutrin and Lexapro
- A breakdown between the specifics of Wellbutrin vs Lexapro
- Lexapro vs Wellbutrin: how to decide which medication is better for you
- Using Lexapro and Wellbutrin together
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Rated For Bipolar I Disorder Report
Not for the anxious This medication made my anxiety sky rocket. I seriously do not reccomend if you have any kind of anxiety problem. I couldnt sleep, felt like I drank 50 pots of coffee and couldnt leave the house. Plus it did nothing for my depression. I did have energy, just the wrong kind. Beware if you have any anxiety disorder, this one is only good for straight depression I believe.
Wellbutrin Storage & Disposal
Wellbutrin should be kept at room temperature and away from light, excess heat and moisture. Keep it in a child proof container in a safe location that is out of reach and sight of children to prevent access for young children.
Medication that is not needed anymore should be disposed of properly to ensure that other people, children and pets are not able to consume it. If you are unsure of how to dispose of the medication, contact your doctor or your local pharmacist.
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Signs Wellbutrin Is Working
So you have been taking Wellbutrin for a couple of weeks now and are wondering if the medication is even working. That is, of course, a legitimate concern, as it will inform whether you need to adjust your dosage or shift to a different medication altogether.
Does Wellbutrin work immediately? Of course not. Like any other depressant, it may take up to 6 weeks and even longer for you to feel the full effects of the medication. During this time, your doctor may adjust the dosage a few times. For some people, it may take a little shorter time to start feeling better. For Wellbutrin, the therapeutic effects begin to appear after about 2-3 weeks of regular use.
Again, you should always keep in mind that antidepressants affect everyone differently, and telling if they are working may not always be that easy.
That being said, how to know the Wellbutrin anxiety is working is based on your specific mental health symptoms. An improvement in these symptoms is a sure sign that these symptoms are the only sure assessment of the effectiveness of the medication. This is one of the reasons why it is crucial to keep a journal of your symptoms and track any improvements.
- Feel less nervous about specific situations
- Become more enthusiastic about certain things and situations
- Concentrate better
- Have better memory
What To Take With Wellbutrin For Anxiety
If you and your provider determine that Wellbutrin is the best prescription medication for your unique circumstance, you may experience anxiety from time to time.
Should the anxiety symptoms interfere with your daily functioning, ask your healthcare provider about their suggestions for alleviating your anxiety.
Natural remedies for anxietylike routine exercise, mindfulness and meditation, and psychotherapycan also help you manage anxiety related to Wellbutrin. If anxiety is extreme, your provider may consider changing to a different type of medication.
In some cases, a doctor may recommend both Wellbutrin and an SSRI or SNRI medication.
For acute episodes of anxiety or panic attacks related to Wellbutrin, you may also be prescribed a short-acting anti-anxiety medication like benzodiazepine or hydroxyzine .
But because these drugs have a higher risk of side effects, and because benzodiazepines are habit-forming, they are not good long-term options. Your doctor may prefer to manage your anxiety with a different medication option instead.
Its important to follow your providers instructions if you do take Wellbutrin. For example, alcohol should not be mixed with Wellbutrin because it can increase Wellbutrins side effects and make depression worse.
Certain prescription medications or supplements may also interact with Wellbutrin, so be sure to consult with your healthcare provider for medical advice before starting anything new.
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Is Wellbutrin Used For Anxiety
Antidepressant medications are not just for depressionthey are also a common treatment for patients with anxiety.
Currently, Wellbutrinalso known as Zybanis approved by the Food and Drug Administration for treating depression, seasonal affective disorder, smoking cessation, and sexual side effects related to selective serotonin reuptake inhibitor medications.
Depending on the circumstance, doctors may also prescribe Wellbutrin for certain types of anxiety.
Wellbutrin XL has been shown in one clinical trial to be as effective for anxiety as escitalopram , a common antidepressant doctors prescribe for patients with anxiety.
Some research also suggests Wellbutrin can help mitigate anxiety symptoms related to depression. If youre using Wellbutrin to quit smoking or help with sexual dysfunction from an SSRI, it may also help reduce situational sources of stress and anxiety.
For some people, however, wellbutrin can make anxiety worse, especially for the first few weeks after starting the medication, or just after a dose change.
Whether your provider recommends Wellbutrin for anxiety depends on a number of factors, including your specific diagnosis, symptoms, and potential drug interactions.
What Other Side Effects Should I Be Aware Of
Besides anxiety, Wellbutrin has several other potential side effects:
- Sleep disturbances
These are the most common, generally mild side effects, and they do not differ much from the side effects of other common medications prescribed for mental health conditions.
However, there are some rarer, more serious side effects as well. These include:
- New or worsening suicidal thoughts
- Manic episodes, especially in people who have bipolar disorder
- Paranoia, delusions, and hallucinations
- Certain eye problems, including pain, swelling, and redness of the eyes
- Severe allergic reactions
These side effects are much less common, and usually only occur in people who are taking high doses of Wellbutrin.
Because of these side effects, there are many common misconceptions and myths surrounding Wellbutrin usage, which may be the source of some of your concerns and questions. Lets take a look at a few.
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What Are The Drug Interactions Of Lexapro Vs Wellbutrin
Lexapro drug interactions
- All SSRIs, including Lexapro, should not be combined with drugs in the monoamine oxidase inhibitor class of antidepressants such as isocarboxazid , phenelzine , tranylcypromine , selegiline and procarbazine or other drugs that inhibit monoamine oxidase such as linezolid and intravenous methylene blue. Such combinations may lead to confusion, high blood pressure, high fevers, tremor or muscle rigidity, and increased activity. At least 14 days should elapse after discontinuing Lexapro before starting an MAO inhibitor. Conversely, at least 14 days should elapse after discontinuing an MAO inhibitor before starting Lexapro.
- Similar reactions occur when SSRIs are combined with other drugs that increase serotonin in the brain, for example tryptophan, St. John’s wort, meperidine , lithium , triptans , and tramadol
- Use of selective serotonin inhibitors may increase the risk of gastrointestinal bleeding in patients taking warfarin , aspirin, nonsteroidal anti-inflammatory drugs , and other drugs that cause bleeding.
Wellbutrin drug interactions
How Do You Know Effexor Is Working
Like with any other medication such as antibiotics and painkillers, once taken the symptoms start to reduce slowly. For example, when you have a headache and pop an Asprin, your headache reduces gradually. Similarly, with antidepressants, the symptoms start to reduce. Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.
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Wellbutrin For Bipolar Disorder
Wellbutrin has been proven to be useful in treating bipolar depression and bipolar disorder in combination with certain other medicines.
Based on various tests carried out, bupropion was effective in managing bipolar disorder and depression when used in combination with Idazoxan, Topiramate, Zoloft, and Venlafaxine. However, a placebo group was absent in this study, which warrants further research on the efficacy of Wellbutrin for bipolar disorder.
What Is Wellbutrin Used For
Bupropion belongs to antidepressants, but Wellbutrin is neither an MAOI nor an SSRI. It is a norepinephrine-dopamine reuptake inhibitor that works by increasing the number of certain neurotransmitters in the brain which are responsible for good mood and a general feeling of well-being. This is why it is used for several health conditions, such as GAD, MDD, ADHD, and OCD. So, What is Wellbutrin used to treat?
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What Are The Side Effects Of Lexapro Vs Wellbutrin
Lexapro side effects
- irritability, or
- poor mood.
In order to avoid these symptoms, the dose of SSRI can be slowly reduced instead of abruptly stopped.
Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of Lexapro or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared with placebo in adults beyond 24 years of age. There was a reduction in risk of suicidality with antidepressants compared with placebo in adults 65 years of age and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients who are started on therapy with antidepressants should be closely observed for clinical worsening, suicidality, or unusual changes in behavior.
Common side effects of Lexapro
Common side effects associated with Lexapro include
- agitation or restlessness,
Wellbutrin side effects
Four of every 1000 persons who receive bupropion in doses less than 450 mg/day experience seizures. When doses exceed 450 mg/day, the risk increases ten-fold. Other risk factors for seizures include past injury to the head and medications that can lower the threshold for seizures.
The most common side effects associated with bupropion include: